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陈竺的“系统生物医学”救不了中医
作者:王澄  文章来源:医学八号楼  点击数  更新时间:2008-3-7 11:30:59  文章录入:huangyf81  责任编辑:huangyf81

参考文献REFERENCES AND NOTES

1. M. Gerstein, N. Lan, R. Jansen, Science 295, 284 (2002) [Abstract/Free Full Text] .

2. S. Brenner, in The Limits of Reductionism in Biology, G. Bock and J. A. Goode, Eds. (Novartis Found. Sym. 213, John Wiley, London, 1998), pp. 106-116.

3. D. Noble and Y Rudy, Philos. Trans. R. Soc. London Ser. A Math. Phys. Sci. Math. Phys. Sci. 359, 1127 (2001) .

4. C. Antzelevich, et al., Philos. Trans. R. Soc. London Ser. A Math. Phys. Sci. 359, 1201 (2001) [CrossRef].

5. M. R. Boyett, et al., Philos. Trans. R. Soc. London Ser. A Math. Phys. Sci. 359, 1091 (2001) [CrossRef].

6. A. Nygren, L. J. Leon, W. R. Giles, Philos. Trans. R. Soc. London Ser. A Math. Phys. Sci. 359, 1111 (2001) [CrossRef].

7. R. L. Winslow, et al., Philos. Trans. R. Soc. London Ser. A Math. Phys. Sci. 359, 1187 (2001) [CrossRef].

8. C. E. Clancy and Y. Rudy, Nature 400, 566 (1999) [CrossRef] [Medline] .

9. Q. Chen, et al., Nature 392, 293 (1998) [CrossRef] [Medline] .

10. D. Noble and P. J. Noble, J. Physiol. (London) 518, 2P (1999) .

11. F. T. Ch'en et al., Prog. Biophys. Mol. Biol. 69, 515 (1998).

12. D. Noble, Ann. N.Y. Acad. Sci., in press.

13. P. Kohl and F. Sachs, Philos. Trans. R. Soc. London Ser. A Math. Phys. Sci. 359, 1173 (2001) [CrossRef].

14. D. Noble, J. Levin, W. Scott, Drug Discov. Today 4, 10 (1999) [CrossRef] [ISI] [Medline].

15. D. Noble and T. J. Colatsky, Emerg. Ther. Targets 4, 39 (2000) .

16. Y. Watanabe and J. Kimura, Br. J. Pharmacol. 131, 80 (2000) [CrossRef] [ISI] [Medline] .

17. G. Bock, J. A. Goode, Eds., Complexity in Biological Information Processing (Novartis Foundation Symposium 239,Wiley, London, 2001).

18. G. Bock, J. A. Goode, Eds., In Silico Simulation of Biological Processes (Novartis Foundation Symposium 247, Wiley, London, in press).

19. I. LeGrice et al Philos. Trans. R. Soc. London Ser. A Math. Phys. Sci. 359, 1217 (2001).

20. K. D. Costa, J. W. Holmes, A. D. McCulloch, Philos. Trans. R. Soc. London Ser. A Math. Phys. Sci. 359, 1233 (2001) [CrossRef].

21. P. Kohl et al Philos. Trans. R. Soc. London Ser. A Math. Phys. Sci. 358, 579 (2000).

22. D. P. Nickerson, N. P. Smith, P. J. Hunter, Philos. Trans. R. Soc. London Ser. A Math. Phys. Sci. 359, 1159 (2001) [CrossRef].

23. C. P. Bradley, A. J. Pullan, P. J. Hunter, Annu. Biomed. Eng. 25, 96 (1997) .

24. D. M. McQueen and C. S. Peskin, Comput. Graph. 34, 56 (2000) .

25. S . Kovacs, D. M. McQueen and C. S. Peskin, Philos. Trans. R. Soc. London Ser. A Math. Phys. Sci. 359, 1299 (2001) [CrossRef].

26. N. P. Smith and G. S. Kassab, Philos. Trans. R. Soc. London Ser. A Math. Phys. Sci. 359, 1251 (2001) [CrossRef].

27. A. Panfilov and A. Pertsov, Philos. Trans. R. Soc. London Ser. A Math. Phys. Sci. 359, 1315 (2001) [CrossRef].

28. See www.research.ibm.com/bluegene/index.html

29. See, for example, www.afcs.org

30. See www.physiome.org

31. See www.physiome.org.nz

32. See www.cds.caltech.edu/erato/sbml/docs/index.html

33. See www.cellml.org

34. X. X. Yan and C. Antzelevich, Circulation 98, 1928 (1998) [ISI] [Medline] .

35. A. L. Muzikant and R. C. Penland, Curr. Opin. Drug Discov. Dev. 5(1), 127 (2002) [ISI] [Medline]

36. See www.physiome.com

37. D. DiFrancesco and D. Noble, Philos. Trans. R. Soc. London Ser. B Biol. Sci. 307, 353 (1985) [ISI] [Medline] .

38. Work in the author's laboratory is supported by the British Heart Foundation, Medical Research Council, Wellcome Trust, and Physiome Sciences Inc.

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(王澄医生 2007年12月17日)

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