一站通用户名: 密码 注册
中医人旗下网站:医学眺望医师考试认识中医人日文英文
 
您现在的位置: 中医人 >> 中医学院 >> 疾病治疗 >> 正文

广告赞助more>>

中医药防治老年性痴呆研究中几个关键问题的思考

  • 文章导读:老年性痴呆(阿尔茨海默病,Alzheimer'sdisease,AD)是一种原因未明、以认知功能减退为主要临床表现的神经系统退行性疾病,已成为世界范围内危害人类健康最严重的疾病之一。中医药防治AD的研究是近年的研究热点。为深入开展AD防治的研究,寻找有效的防治方法,改善和提高患者的生存质量,结合AD现代医学研究进展,就中医药防治AD研究中的几个重要问题进行了较为系统的阐述。强调在中医药防治AD的研究中应注重科学地选择和应用权威的AD临床诊断标准;选择多因素复合动物模型;注意AD的肾虚本质特征和病因病机特点;注意观察指标特异性、敏感性和稳定性的综合考虑,强调功能整合水平观察指标的评价;充分认识中药复方的多途径、多靶点作用优势,开展严格的随机盲法对照临床试验。

    基金项目:国家“九五”科技重点攻关课题,编号:96-906-09-02

      作者简介:第一作者,赖世隆 男,1940年出生,教授,博士生导师;

      参考文献:

      [1]Martin M,Schellenberg G D, Wijsman M E, et al. Dominant susceptibility genes[J], Nature, 1990,347:124

      [2]杨雄里.神经科学[M].北京:中国科技技术出版社,1991.137

      [3]张明圆,瞿光亚,王征宇,等.痴呆和Alzheimer病的患病率研究[J].中华医学杂志,1990,70(8):424

      [4]Katzman R.Advances in the diagnosis of dementia:Accuracy of diagnosis and consequences of misdiagnosis of disorders causing dementia[M].In:Terry RD,Aging and Brain,1988.17~62

      [5]Buck B H, Black S E, Behrmann M,et al. Spatial-and-object based attentional deficits in Alzheimer's disease: Relationship to HMPAO-SPECT measure of parietal perfusion[J]. Brain, 1997,120:1229

      [6]Tohgi H, Yonezawa H, Takahashi S, et al. Cerebral blood flow and oxygen metabolism in senile dementia of Alzheimer's type and vascular dementia with deep white matter change [J].Neuroradiology,1998,40:131

      [7]Cummings J L, Benson D F.Dementia of the Alzheimer type:an inventory of diagnostic clinical features [J].J Am Geriatr Soc, 1986,34(1):12

      [8]Connor DJ,Langlais PJ,Leon J.Behavioral impairments after lesions of the nucleus basalis by ibotenic acid and quisqualic acid[J].Brain Res,1991,555:84

      [9]龙大宏,姚志斌,何蕴韶,等.神经生长因子(NGF)对基底前脑 NGE 受体阳性神经元损伤后的保护作用[J].神经解剖学杂志,1995,11:13

      [10]Fisher A, Hanin l. Potential animal models for senile dementia of Alzheimer's type, with emphasis of AF64A-induced cholinotoxicity[J].Annual Review of Pharmacology and Toxicology, 1986,26:161

      [11]Fisher A, Hanin l. Minireview:choline analogues as potential tools in developing selective animal models of central cholinergic hypofunction [J]. Life Sci, 1980, 27:1615

      [12]Perl D, Brody AR. Alzheimer's disease: X_ray spectrometric evidence of aluminum accumulation in neurofibrillary tangle-bearing neurons[J].Science, 1980,208:197

      [13]Klatzo l, Wisniewski H M, Streicher E.Experimental production of neurofibrillary degeneration[J]. J Neuropathol Exp Neurol,1965,24:187

      [14]Crapper DR, Dalton AJ. Alterations in short-term retention, conditioned avoidance response acquisition and motivation following aluminum induced neurofibrillary-degeneration[J].Physiol Behav, 1973,10:925

      [15]罗焕敏,姚志彬,陈以慈.当归芍药散改良方对老年性痴呆鼠空间记忆力的影响[J].中国老年学杂志,1995,15(5):283

      [16]韩景献.老化模型小白鼠(SAM)的老化诸特征[J].实验动物科学与管理,1995,12(4):21

      [17]Arendt T,Holzer M, Fruth R, et al.Phosphorylation of Tau, Aβ-Formation, and apotosis after in vivo inhibition of PP-1 and PP-2A[J].Neurobiol of Aging, 1998,19(1):3

      [18]Games D, Adams D, Alessandrini R, et al. Alzheimer-type neuropathology in transgenic mice overexpressing v717 β-amyloid precursor protein[J].Nature, 1995, 373:523

      [19]秦川,常洋,朱华,等.早老性痴呆转基因小鼠的研究[J].中国老年学杂志,2000,20(1):31

      [20]Rubinsztein D C. The genetics of Alzheimer's disease progress in neurobiology [J].Progress in Neurobiology, 1997,52:447

      [21]Greenberg BD, Savage MJ, Howland D S, et al. APP transgenesis: Approaches toward the development of animal models for Alzheimer's disease neuropathology[J]. Neurobiol of Aging, 1996,17:153

      [22]胡镜清,赖世隆,王奇,等.D-半乳糖加速衰老合并Meynert核损毁大鼠学习记忆能力变化的初步观察[J].中华老年医学杂志,2000,19(2):5

      [23]胡镜清,赖世隆,王奇,等.补肾益智方对阿尔茨海默病大鼠模型脑内胆碱能神经系统的保护作用[J].广州中医药大学学报,1999,16(3):201

      [24]胡镜清,赖世隆,梁伟雄,等.AD模型大鼠海马CA1区SSmRNA表达水平的变化及补肾益智方的保护作用[J].福建中医药,1999,30(增刊):21

      [25]颜德馨.老年性痴呆与瘀血的关系[J].辽宁中医杂志,1991(8):37

      [26]郭振球.老年期痴呆的证治学研究[J].中医药研究,1991(1):16

      [27]傅仁杰,罗社文.中医药治疗老年性呆病的临床研究述评[J].北京中医药大学学报,1994,17(3):2

      [28]傅陆,杜凯.老年痴呆的辨证治疗[J].新中医,1992(2):49

      [29]杨柏灿,林水淼,刘仁人,等.Azheimer痴呆的中医病因病机探析[J].中国中医基础医学杂志,1999,5(1):51

      [30]田金洲,杨承芝,盛彤,等.可疑痴呆人群中阿尔茨海默氏病临床前的认识损害特征及其与中医证候的关系[J].湖北中医学院学报,1999,1(4):49

      [31]Dvis K L, Thal L J,Garmzu ER, et al. A double-blind, placebo-controlled multicenter study of tacrine for Alzheimer's disease[J].New Engl J Med,1992, 327(8):1253

      [32]饶燕,王奇,赖世隆.补肾益智方对实验性Alzheimer病大鼠学习记忆和海马长时程增强的影响[C].见:中国神经科学学会第三届全国学术会议论文摘要汇编,1999.278

      [33]Khachaturian ZS. The prospect of developing treatments for Alzheimer's disease[M]. ln: Terry RD. Alzheimer's disease. New York: Raven Press,1994.445~452

      [34]孙秀湘,贾谦.以美国为突破口加速中药国际化[J].世界科学技术——中药现代化,1999(1):45

      [35]胡镜清,赖世隆.阿茨海默病病理进展与中药可能干预途径[J].广州中医药大学学报,1997,14(2):125

      [36]陈楷,陈可冀.老年期痴呆研究进展[J].中国中西医结合杂志,1995,15(2):120

    上一页  [1] [2] [3] 

    昵称:  (欢迎留言,注意文明用词!
      评分: 1分 2分 3分 4分 5分
      内容:
    * 所有评论仅代表网友意见,中医人保持中立