十五、提高丙型肝炎患者对治疗的依从性
患者的依从性是影响疗效的一个重要因素。医生应在治疗开始前向患者详细解释本病的自然病程,并说明抗病毒治疗的必要性、现有抗病毒治疗的疗程、疗效及所需的费用等。还应向患者详细介绍药物的不良反应及其预防和减轻的方法,以及定期来医院检查的重要性,并多给患者关心、安慰和鼓励,以取得患者的积极配合,从而提高疗效。
参 考 文 献
[1]Alberti A, Benvegnu L. Management of hepatitis C. J Hepatol, 2003, 38(suppl 1): S1014-S118.
[2]Booth JCL, O扜rady J, Neuberger J. Clinical guidelines on the management of hepatitis C. Gut, 2001, 49(suppl I): i1-i12.
[3]Camma C, Bruno S, Schepis F, et al. Retreatment with interferon plus ribavirin of chronic hepatitis C non-responders to interferon monotherapy: a meta-analysis of individual patient data. Gut, 2002, 51: 864-869.
[4]Chander G, Sulkowski MS, Jenckes MW, et al. Treatment of chronic hepatitis C: a systemic review. Hepatology, 2002, 36(5 suppl 1): S135-S144.
[5]Di Ciommo V, Russo P, Rava L, et al. Interferon alpha in the treatment of chronic hepatitis C in children: a meta-analysis. J Viral Hepatol, 2003, 10: 210-214.
[6]Fabrizi F, Dulai G, Dixit V, et al. Meta-analysis: interferon for the treatment of chronic hepatitis C in dialysis patients. Aliment Pharmacol Ther, 2003, 18: 1071-1081.
[7]Kjaergard LL, Krogsgaard K, Gluud C. Interferon alfa with or without ribavirin for chronic hepatitis C: systematic review of randomised trials. BMJ, 2001, 323: 1151-1155.
[8]National Institute of Health Consensus Development Conference Statement: management of hepatitis C. Hepatology, 2002, 36:(5 Suppl 1): S3-20.
[9]Papatheodoridis GV, Papadimitropoulos VC, Hadziyannis SJ. Effect of interferon therapy on the development of hepatocellular carcinoma in patients with hepatitis C virus-related cirrhosis: a meta-analysis. Aliment Pharmacol Ther, 2001, 15:689-698.
[10]Poynard T, McHutchison J, Davis GL, et al. Impact of interferon alfa-2b and ribavirin on progression of liver fibrosis in patients with chronic hepatitis C. Hepatology, 2000, 32: 1131-1137.
[11]戴志澄, 齐国明. 中国病毒性肝炎: 血清流行病学调查(上卷), 北京: 科学技术文献出版社, 1997, 60-71.
[12]康来仪, 孙永德, 郝连杰, 等. 我国丙型和戊型肝炎人群流行病学调查及流行因素的研究. 中华传染病杂志, 1997, 15: 71-75.
[13]谢尧, 徐道振, 陆志檬, 等. HCV基因型对慢性丙型肝炎干扰素疗效的影响. 中华肝脏病杂志, 2004, 12: 72-75.
[14]庄辉, Tracy L, 崔怡辉, 等. 我国部分地区HCV基因分型研究. 中华流行病学杂志, 2001, 22: 99-101.
[15]中华医学会传染病与寄生虫病分会和肝病分会. 病毒性肝炎防治防治方案. 中华肝脏病杂志, 2000, 8: 324-329.